Pharmacological knockout of endothelin ET_A receptors

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• 作者：Taniguchi ; Takanobu ; Muramatsu ; Ikunobu
• 关键词：Endothelin ; ET_A ; Antagonist ; Ductus arteriosus
• 刊名：Life Sciences
• 出版年：2003
• 出版时间：December 5, 2003
• 年：2003
• 卷：74
• 期：2-3
• 页码：405-409
• 全文大小：169 K

文摘

We employed newly developed antagonists, which are specific for endothelin ET_A receptors, to test whether this drug could mimic the phenotype of the mouse with corresponding gene knock out. Newborn rats, whose dams were given the ET_A antagonist from day 7 of gestation, exhibited the typical ET_A-lacking phenotypes like craniofacial abnormalities and major vessel anomalies. Interestingly, craniofacial abnormality was seen in the pups that were exposed to the drug in the mid-gestational period, while another phenotype, patent ductus arteriosus (DA), was seen in the pups that were exposed to the drug in the late gestation.