Tankyrase 2 (TNKS2) polymorphism associated with risk in developing non-small cell lung cancer in a Chinese population

详细信息    查看全文

• 作者：Ying Wang^a ; Weiyu Jiang^b ; Xiaogu Liu^a ; Yongjun Zhang^c ; ^{zhangyj@zjcc.org.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Non-small cell lung cancer ; Genetic susceptibility ; TNKS2 ; Single nucleotide polymorphisms
• 刊名：Pathology - Research and Practice
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：211
• 期：10
• 页码：766-771
• 全文大小：435 K

文摘

We investigated the association between poly(ADP-ribose) polymerase Tankyrase 2 (TNKS2) single-nucleotide polymorphisms (SNPs) and the risk of developing non-small cell lung cancer (NSCLC) in a Han Chinese population.

Methods

Five-hundred NSCLC cases and 500 healthy controls were genotyped for four TNKS2 tagging SNPs (rs1538833, rs1538833, rs1340420, and rs1340420). The association between genotype and NSCLC risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) using multivariate unconditional logistic regression analyses.

Results

Individual alleles of the four TNKS2 SNPs were not associated with NSCLC risk in the studied Chinese population. However, patients carrying TNKS2 rs1340420 G/G and A/G genotypes were associated with a lower risk of developing NSCLC and adenocarcinoma (OR = 0.14; 95% CI = 0.02–1.15 and OR = 0.11; 95% CI = 0.03–0.91, respectively), whereas females patients homozygous for the TNKS2 rs1770474 T allele, a rare type, were associated with a higher risk of developing squamous-cell carcinoma (SCC) (OR = 4.67; 95% CI = 0.87–25.01).

Conclusion

TNKS2 rs1340420 SNP was associated with lower NSCLC risk, whereas rs1770474 SNP was associated with higher SCC risk, suggesting that these two SNPs may be useful predictors of risk of developing NSCLC and SCC in this Chinese population.