Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling
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- 作者：Amanda A. Riccio1 ; Michael McCauley2 ; Marie-France Langelier1 ; John M. Pascal1 ; john.pascal@umontreal.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：tankyrase ; poly(ADP-ribose) polymerase ; Wnt/β-catenin signaling ; X-ray crystallography
- 刊名：Structure
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：24
- 期：9
- 页码：1573-1581
- 全文大小：3130 K
文摘
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Crystal structure of the wild-type SAM domain polymer of human Tankyrase-1 (TNKS1)
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Structure-based SAM domain mutagenesis disrupts TNKS1 polymerization in cells
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TNKS1 function in cytoplasmic Wnt signaling complexes requires SAM polymerization
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SAM polymer is a key regulator of TNKS1 catalytic activity in signaling complexes