Gut microbiota composition and relapse risk in pediatric MS: A pilot study

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• 作者：Helen Tremlett^a ; ^{helen.tremlett@ubc.ca" class="auth_mail" title="E-mail the corresponding author} ; Douglas W. Fadrosh^b ; Ali A. Faruqi^b ; Janace Hart^b ; Shelly Roalstad^c ; Jennifer Graves^b ; Susan Lynch^b ; Emmanuelle Waubant^b ; on behalf of the US Network of Pediatric MS CentersGreg Aaen¹ ; Anita Belman² ; Leslie Benson³ ; Charlie Casper⁴ ; Tanuja Chitnis³ ; Mark Gorman³ ; Yolanda Harris⁷ ; Lauren Krupp² ; Tim E. Lotze⁶ ; Sabina Lulu⁷ ; Jayne Ness⁵ ; Cody Olsen⁴ ; Erik Roan⁴ ; Moses Rodriguez⁵ ; John Rose⁴ ; Timothy C. Simmons⁴ ; Jan-Mendelt Tillema⁵ ; Wendy Weber⁴ ; Bianca Weinstock-Guttman⁸
• 关键词：Pediatric multiple sclerosis ; Gut microbiota ; 16S rRNA ; Relapse risk ; Survival analyses ; Kaplan-Meier ; Cox regression
• 刊名：Journal of the Neurological Sciences
• 出版年：2016
• 出版时间：15 April 2016
• 年：2016
• 卷：363
• 期：Complete
• 页码：153-157
• 全文大小：807 K

文摘

<dl class="listitem" id="list_l0005"><dt class="label">•dt><dd>

d="p0005">Gut microbiota was associated with subsequent relapse risk in pediatric multiple sclerosis.

dd><dt class="label">•dt><dd>

d="p0010">Fusobacteria depletion increased relapse risk (hazard ratio = 3.2; 95% CI: 1.2&ndash;9.0).

dd><dt class="label">•dt><dd>

d="p0015">Findings could offer new targets to alter the MS disease course.

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