Toll-interacting protein deficiency promotes neurodegeneration via impeding autophagy completion in high-fat diet-fed ApoE^−/− mouse model

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• 作者：Keqiang Chen^a ; ¹ ; Ruoxi Yuan^a ; ^b ; ¹ ; Shuo Geng^a ; Yao Zhang^a ; Taojing Ran^a ; Elizabeth Kowalski^a ; Jingze Liu^c ; Liwu Li^a ; ^b ; ^lwli@vt.edu
• 关键词：ApoE ; apolipoprotein E ; Tollip ; Toll-interacting protein ; HFD ; high fat diet ; TEM ; transmission electron microscopy ; AVs ; autophagic vacuoles
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：200-210
• 全文大小：4440 K
• 卷排序：59

文摘

Tollip deficiency exacerbated neuronal cell death in mouse brain. Tollip deficiency caused accumulation of β amyloid and α-synuclein. Tollip deficiency affected autophagy as manifested in elevated levels of p62 and Parkin.