Insulin-like growth factor 1 promotes the proliferation and committed differentiation of human dental pulp stem cells through MAPK pathways
详细信息 查看全文
- 作者：Taohong Lva ; 1 ; Yongzheng Wua ; 1 ; Chao Mua ; Genxia Liuc ; Ming Yanb ; Xiangqin Xua ; Huayin Wua ; Jinyin Dua ; Jinhua Yu ; Ph.D ; DDSb ; c ; yujinhua@njmu.edu.cn" class="auth_mail" title="E-mail the corresponding author (Professor ; Vice Director) ; Jinquan Mu ; DDSa ; dentmjq@163.com" class="auth_mail" title="E-mail the corresponding author (Lecturer)
- 关键词：ALP ; alkaline phosphatase ; a-MEM ; a-minimum essential medium ; BMPs ; bone morphogenetic proteins ; CPC ; cetyl pyridinium chloride ; DSP ; dentin sialoprotein ; DSPP ; dentin sialophosphoprotein ; ERK ; extracellular regulated protein kinases ; FBS ; fetal bovine serum ; FGFs ; fibroblast growth factors ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; HDPSCs ; human dental pulp stem cells ; IGF-1 ; insulin-like growth factor 1 ; IGFs ; insulin-like growth factors ; JNK ; c-Jun N-terminal kinase ; MAPK ; mitogen-acti
- 刊名：Archives of Oral Biology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：72
- 期：Complete
- 页码：116-123
- 全文大小：1843 K
文摘
- listitem" id="list_lis0005">
- •
IGF-1 can up-regulate the ALP activity and mineralization capacity of hDPSCs.
- •
MAPK signaling pathway is activated during the differentiation of hDPSCs.
- •
IGF-1 promotes the proliferation and osteogenic/odontogenic differentiation of hDPSCs.