Pharmacokinetic/pharmacodynamic adequacy of echinocandins against Candida spp. in intensive care unit patients and general patient populations
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- 作者：Qianting Yang ; Taotao Wang ; Jiao Xie ; Yan Wang ; Xiaowei Zheng ; Lu Chen ; Ying Li ; Ti Meng ; Yalin Dong ; dongyalin@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; dongyalin@medmail.com.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Echinocandin ; Candida ; Intensive care unit ; Cumulative fraction of response ; Pharmacokinetic/pharmacodynamic
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：47
- 期：5
- 页码：397-402
- 全文大小：468 K
文摘
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First study of PK/PD target attainment of echinocandins in critically ill patients.
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Considerable PTA variability was observed for anidulafungin and micafungin in different patient populations.
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For Candida albicans and C. glabrata, caspofungin is a reasonable choice for general and ICU patients.
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For C. parapsilosis, an increased dose up to 100 mg once daily of caspofungin is needed.
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For anidulafungin and micafungin, administering higher doses is needed in clinical applications.