Chemoenzymatic asymmetric synthesis of fluoxetine, atomoxetine, nisoxetine, and duloxetine

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• 作者：Rohan Kalyan Rej ; Tapas Das ; Suman Hazra ; Samik N ; a
• 刊名：Tetrahedron: Asymmetry
• 出版年：2013
• 出版时间：31 August, 2013
• 年：2013
• 卷：24
• 期：15-16
• 页码：913-918
• 全文大小：482 K

文摘

The asymmetric synthesis of two well-known anti-depressant drugs, fluoxetine and duloxetine has been accomplished in a chemoenzymatic manner. The main highlight of the synthesis is the enantioselective cyanohydrin formation by a plant (R)-HNL (hydroxynitrile lyase). The enantiopure cyanohydrins are then synthetically manipulated into the above two drug molecules and two of their structural analogues, atomoxetine and nisoxetine.