Aptima HIV-1 Quant Dx—A fully automated assay for both diagnosis and quantification of HIV-1
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- 作者：Sangeetha Vijaysri Nair ; sangeetha.nair@hologic.com" class="auth_mail" title="E-mail the corresponding author ; Hee Cheol Kim ; Jacqueline Fortunko ; Tracy Foote ; Tashi Peling ; Cuong Tran ; Charles Thomas Nugent ; Sunghae Joo ; Youna Kang ; Bana Wilkins ; Kristen Lednovich ; Andrew Worlock
- 关键词：Aptima ; Aptima HIV-1 Quant Dx Assay ; VL ; viral load ; CAP/CTM ; COBAS® ; AmpliPrep/COBAS® ; TaqMan® ; HIV-1 Test v2.0 ; Abbott RT ; Abbott RealTime HIV-1 Assay ; Procleix ; Procleix® ; Ultrio Elite&trade ; discriminatory assay ; LOD ; limit of detection ; LOQ ; limit of quantification ; LLOQ ; lower limit of quantification ; ART ; anti retroviral therapy ; NAAT ; nucleic acid amplification test ; SD ; standard deviation
- 刊名：Journal of Clinical Virology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：46-54
- 全文大小：937 K
文摘
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Aptima was more sensitive than COBAS Ampliprep TaqMan HIV-1 version 2.0 (CAP/CTM).
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In seroconversion panels Aptima detected HIV earlier than antigen/antibody tests.
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Diagnostic agreement was 100% with Procleix® Ultrio Elite™ blood screening assay.
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Viral load measurements in Aptima showed good agreement with CAP/CTM.
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Aptima demonstrated equivalent subtype quantification and good precision.