Highly efficient resolution of (±)-Tramadol with di-p-toluoyl-tartaric acid (DTTA)

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• 作者：Evans ; Graham R. ; Henshilwood ; James A. ; O'Rourke ; John
• 刊名：Tetrahedron: Asymmetry
• 出版年：2001
• 出版时间：July 4, 2001
• 年：2001
• 卷：12
• 期：11
• 页码：1663-1670
• 全文大小：131 K

文摘

A robust and efficient resolution of (±)-Tramadol has been developed using di-p-toluoyl-tartaric acid (DTTA). Both enantiomers have been efficiently separated and isolated in high chemical and optical purities. This requires the use of both antipodes of DTTA.