The function of glucagon-like peptide-1 in the mouse peripheral taste system

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• 作者：Shingo Takai^a ; Ryusuke Yoshida^a ; Keiko Yasumatsu^b ; Noriatsu Shigemura^a ; Yuzo Ninomiya^a ; ^b ; ^{ninomoiya.yuzo.285@m.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CALHM1 ; calcium homeostasis modulator protein 1 ; CCK ; cholecystokinin ; CT ; chorda tympani ; CV ; circumvallate papillae ; FP ; fungiform papillae ; GIP ; gastric inhibitory polypeptide ; GLP-1 ; glucagon-like peptide-1 ; GLP-1R ; glucagon-like peptide-1 receptor ; LCFA ; long chain fatty acid ; NTS ; nucleus of the solitary tract ; P2X2/3 ; purinergic receptor 2/3 ; TCs ; taste cells ; TRPM5 ; transient receptor potential cation channel subfamily M member 5 ; VIP ; vasoactive intestinal peptide
• 刊名：Journal of Oral Biosciences
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：58
• 期：1
• 页码：10-15
• 全文大小：1354 K

文摘

Several studies have demonstrated that some gut peptides known to be important in energy metabolism are expressed in mouse taste bud cells. However, the functions of these peptides in taste cells are still largely unknown. In the gut, one of these peptides, glucagon-like peptide-1 (GLP-1), which is known as the insulinotropic gut peptide, is secreted from enteroendocrine L-cells, which express as many taste molecules as those on the tongue. These taste transduction molecules are suggested to be involved in GLP-1 secretion from L-cells in response to various nutrient stimuli. GLP-1 is reported to function as a neurotransmitter via activation of its receptors expressed on the vagus nerve, thereby regulating insulin secretion.

Highlight

Consistent with this evidence from the gastrointestinal tract, recent studies have demonstrated that GLP-1 is secreted from mouse taste cells in response to taste compounds such as sugars, artificial sweeteners, and long-chain fatty acids. GLP-1 secreted from taste cells may activate particular types of gustatory nerve fibers because they express GLP-1 receptors and respond to GLP-1 administered via the femoral vein.

Conclusion

GLP-1 released from taste cells may be involved in transmission of sweet and lipid signals, thereby impacting animals׳ feeding behavior in response to these important nutrient factors.