Dimethylfumarate inhibits tumor cell invasion and metastasis by suppressing the expression and activities of matrix metalloproteinases in melanoma cells
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- 作者：Yuzuru Yamazoe ; Masanobu Tsubaki ; Hiroshi Matsuoka ; Takao Satou ; Tatsuki Itoh ; Takashi Kusunoki ; Yasuhiro Kidera ; Yoshihiro Tanimori ; Kaori Shoji ; Haruyuki Nakamura ; Mitsuhiko Ogaki ; Saori Nishiura ; S
- 关键词：Dimethylfumarate ; NF-κ ; B ; MMP ; Metastasis ; Invasion
- 刊名：Cell Biology International
- 出版年：2009
- 出版时间：October 2009
- 年：2009
- 卷：33
- 期：10
- 页码：1087-1094
- 全文大小：816 K
文摘
NF-κB acts as a signal transducer during tumor progression, cell invasion, and metastasis. Dimethylfumarate (DMF) is reported to inhibit tumor necrosis factor-α-induced nuclear entry of NF-κB/p65. However, only a few reports suggest that DMF inhibits tumor metastasis; also the molecular mechanisms underlying the inhibition of metastasis are poorly understood. We investigated the inhibition of tumor invasion and metastasis by DMF in a melanoma cell line, B16BL6. DMF inhibited B16BL6 cell invasion and metastasis by suppressing the expression and activities of MMPs. DMF also inhibited the nuclear entry of NF-κB/p65, thus inhibiting B16BL6 cell invasion and metastasis. These results suggest that DMF is potentially useful as an anti-metastatic agent for the treatment of malignant melanoma.