Multi-epitope proteins for improved serological detection of Trypanosoma cruzi infection and Chagas Disease
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- 作者：Malcolm S. Duthiea ; mduthie@idri.org" class="auth_mail" title="E-mail the corresponding author ; Jeffery A. Guderiana ; Aarthy C. Vallura ; Ayesha Misquitha ; Hong Lianga ; Raodoh Mohamatha ; Alejandro O. Luquettib ; Darrick Cartera ; c ; Suelene N.B. Tavaresb ; Steven G. Reeda
- 关键词：EC ; endemic control ; ELISA ; enzyme-linked immunosorbent assay ; IIF ; indirect immunofluorescence ; NEC ; non-endemic control ; RDT ; rapid diagnostic tests ; TR ; tandem repeat
- 刊名：Diagnostic Microbiology & Infectious Disease
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：84
- 期：3
- 页码：191-196
- 全文大小：984 K
文摘
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Designed novel recombinant fusion proteins combining several reactive tandem repeat proteins (TR) proteins into single diagnostic products for Chagas disease
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Demonstrated that TcF43 and TcF26 antigens enhance detection and strength of signal without compromising the specificity of detection compared to that obtained with TcF, an established fusion antigen used in commercial test for detection of Chagas disease
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TcF43 and TcF26 detect sera with weak reactivity towards TcF with a significantly stronger response.