- 作者：Alain Vergnen猫gre ; St茅phane Hominal ; Achille Edem Tchalla ; Henri B茅rard ; Isabelle Monnet ; Gislaine Fraboulet ; Nathalie Baize ; Clarisse Audigier-Valette ; Gilles Robinet ; G茅rard Oliviero ; Herv茅 Le Caer ; Pascal Thomas ; Laurence G茅rini猫re ; B茅n茅dicte Mastroianni ; Christos Choua茂d ; the GFPC 0804 team
- 关键词：Palliative care ; Non-small-cell lung cancer ; Observational study ; Quality of care ; Economics
- 刊名：Lung Cancer
- 出版年：November, 2013
- 年：2013
- 卷：82
- 期：2
- 页码：353-357
- 全文大小：494 K
Summary
Introduction
Few studies assessed, in real life, symptoms, specific interventions and factors influencing palliative care (PC) initiation for patients with advanced non-small-cell lung cancer (NSCLC). The objective of this study was to examine, in a prospective cohort of advanced NSCLC patients, PC use and factors associated with early (鈮? months after diagnosis) PC initiation.Methods
It was an observational multicenter study. Each center included 10 consecutive patients with PC initiation.
Results
514 patients were enrolled by 39 centers (age: 62.3 卤 10.7 years, performance status: 0/1; 68.6% cases). At baseline, the most frequent symptoms concerned pain (43.6%), malnutrition (37%) and psychological disorders (25.3%). Specific interventions were infrequent for pain control and malnutrition, but were more numerous for psychological and social problems and terminal care. Median time between diagnosis and PC initiation was 35 [13-84] days, median PC duration was 4.2 [0.6-9.3] months. Median overall survival was 8.6 [6.6-10.7] months; median survival after PC initiation was 3.6 [3.2-4.5] months. In multivariate analysis, only PS 鈮? was linked to early PC.
Conclusion
This study showed that early PC initiation is not a standard for patients with advanced NSCLC.