Comparability of antibody response to a booster dose of 7-valent pneumococcal conjugate vaccine in infants primed with either 2 or 3 doses
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- 作者：Gerwin D. Rodenburg ; Elske J.M. van Gils ; Reinier H. Veenhoven ; Nienke Jones ; Irina Tcherniaeva ; Eelko Hak ; Loek van Alphen ; Guy A.M. Berbers ; Elisabeth A.M. S ; ers
- 关键词：Pneumococcal conjugate vaccine ; Immunogenicity ; Reduced-dose schedules
- 刊名：Vaccine
- 出版年：2010
- 出版时间：3 February 2010
- 年：2010
- 卷：28
- 期：5
- 页码：1391-1396
- 全文大小：463 K
文摘
In this cohort study we compared IgG antibody levels between infants immunized with 7-valent CRM197-conjugated pneumococcal vaccine (PCV-7) at 2, 4 and 11 months and at 2, 3, 4 and 11 months of age, as measured by double adsorption ELISA. Pre- and post-booster levels following the 2 + 1- and 3 + 1-dose schedule were comparable for 5 out of 7 serotypes except for serotypes 6B and 19F. The proportion of children reaching post-booster antibody thresholds were comparable except for 6B (≥1.0 μg/ml and ≥5.0 μg/ml) and 19F (≥5.0 μg/ml). Surveillance studies are warranted for vaccine impact on 6B and 19F disease cases after reduced-dose PCV-7 schedules.