Seroprevalence of rubella antibodies in The Netherlands after 32 years of high vaccination coverage

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• 作者：Gaby Smits^a ; ^{Gaby.Smits@rivm.nl" class="auth_mail} ; Liesbeth Mollema^b ; Susan Hahné ; ^b ; Hester de Melker^b ; Irina Tcherniaeva^a ; Fiona van der Klis^a ; Guy Berbers^a
• 关键词：Rubella virus ; Seroprevalence ; Antibody levels ; Cross-sectional population-based serosurveillance study
• 刊名：Vaccine
• 出版年：1 April, 2014
• 年：2014
• 卷：32
• 期：16
• 页码：1890-1895
• 全文大小：1081 K

文摘

Here we present rubella virus specific antibody levels in a large cross-sectional population-based serosurveillance study performed in The Netherlands in 2006/2007.

In the nationwide sample, seroprevalence was high (95%). Higher levels of rubella specific antibodies were observed in the naturally infected cohorts compared with the vaccinated cohorts. After both vaccinations, the geometric mean concentration of rubella specific antibodies remained well above the protective level. However, antibody concentrations decreased faster after one than after two vaccinations. Infants too young to be vaccinated were a risk group in the nationwide sample. In the orthodox protestant group, individuals younger than 6 years of age were at risk for an infection with rubella, consistent with a small local outbreak that recently occurred at an orthodox protestant primary school.

The general Dutch population is well protected against an infection with rubella virus. However, monitoring the rubella specific seroprevalence remains an important surveillance tool to assess possible groups at risk.