An investigation into the formation of tebufenozide's toxic aromatic amine metabolites in human in vitro hepatic microsomes
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- 作者：Khaled M. Abass1 ; khaled.m.abass@gmail.com" class="auth_mail" title="E-mail the corresponding author ; khaled.megahed@oulu.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：Insect growth regulators ; Pesticides ; In vitro biotransformation ; Human hepatic microsomes ; Methemoglobinemia
- 刊名：Pesticide Biochemistry and Physiology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：133
- 期：Complete
- 页码：73-78
- 全文大小：611 K
文摘
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Tebufenozide was metabolized by human hepatic microsomes in vitro.
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Three metabolites were detected from the extracted chromatograms.
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Toxic aromatic amines were not detected in human under in vitro conditions.
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The fate of tebufenozide was a process of detoxification rather than activation.