An advantageous technique to load drugs into aerogels: Gas antisolvent crystallization inside the pores

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• 作者：Zeynep Ulker ; Can Erkey ; ^{cerkey@ku.edu.tr}
• 关键词：Paracetamol ; Gas antisolvent crystallization ; Silica aerogel ; Drug delivery
• 刊名：The Journal of Supercritical Fluids
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：120
• 期：part_P2
• 页码：310-319
• 全文大小：2288 K
• 卷排序：120

文摘

Gas antisolvent crystallization was applied inside the pores of silica aerogels. Solute was loaded via diffusion and crystallized by charging scCO2 in the system. Loading increased with increasing initial concentration of the initial solution. Paracetamol movement was predicted by the drying model and its solubility curve.