The pharmacokinetic characters of simvastatin after co-administration with Shexiang Baoxin Pill in healthy volunteers’ plasma
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- 作者：Jianfei Taoa ; 1 ; Peng Jiangb ; c ; 1 ; Chengcheng Pengd ; Min Lie ; Runhui Liub ; Weidong Zhangb ; d ; wdzhangy@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Simvastatin ; Shexiang Baoxin Pill ; Pharmacokinetics ; Healthy volunteers
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：1026
- 期：Complete
- 页码：162-167
- 全文大小：1192 K
文摘
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Investigated the interaction of pharmacokinetcs of Shexiang Baoxin Pill (SBP) and simvastatin.
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The MRT(0–∞), T1/2 and Tmax values of simvastatin were significantly increased by SBP.
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The AUC(0–t) and Cmax values of smivastatin were also significantly decreased by SBP.
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The potential drug–drug interaction should be noted in the future clinical practice.