Three-Year Results Comparing Platinum-Chromium PROMUS Element and Cobalt-Chromium XIENCE V Everolimus-Eluting Stents in De Novo Coronary Artery Narrowing (from the PLATINUM Trial)

详细信息    查看全文

• 作者：Ian T. Meredith ; AM ; MBBS ; PhD^a ; ^{ian.meredith@myheart.id.au" class="auth_mail} ; Paul S. Teirstein ; MD^b ; Alain Bouchard ; MD^c ; Didier Carrié ; MD ; PhD^d ; Helge Mö ; llmann ; MD^e ; Keith G. Oldroyd ; MD^f ; Jack Hall ; MD^g ; Dominic J. Allocco ; MD^h ; Keith D. Dawkins ; MD^h ; Gregg W. Stone ; MDⁱ
• 刊名：The American Journal of Cardiology
• 出版年：1 April, 2014
• 年：2014
• 卷：113
• 期：7
• 页码：1117-1123
• 全文大小：1247 K

文摘

In the randomized PLATINUM trial, the PROMUS Element platinum-chromium everolimus-eluting stent (PtCr-EES; Boston Scientific, Natick, Massachusetts) was noninferior to the XIENCE V cobalt-chromium everolimus-eluting stent (CoCr-EES; Boston Scientific and Abbott Vascular, Santa Clara, California) for the primary end point of 1-year target lesion failure. This study reports the 3-year outcomes. Patients (n聽= 1,530) with 1 or 2 de novo native coronary artery lesions (baseline vessel diameter 鈮?.50聽mm to 鈮?.25聽mm and length 鈮?4聽mm) were randomized 1:1 to PtCr-EES versus CoCr-EES. Three-year follow-up was available in 93.9% (703 of 749) of patients with CoCr-EES and 96.7% (733 of 758) of patients with PtCr-EES. Comparing CoCr-EES with PtCr-EES, 3-year rates of death (4.3% vs 3.7%, hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.52 to 1.48, p聽= 0.62), cardiac death (1.9% vs 1.2%, HR 0.63, 95% CI 0.27 to 1.45, p聽= 0.27), myocardial infarction (2.5% vs 2.3%, HR 0.92, 95% CI 0.48 to 1.79, p聽= 0.81), ischemia-driven target lesion revascularization (4.9% vs 3.5%, HR 0.72, 95% CI 0.43 to 1.20, p聽= 0.21), and Academic Research Consortium definite or probable stent thrombosis (0.5% vs 0.7%, HR 1.23, 95% CI 0.33 to 4.57, p聽= 0.76) were not significantly different. In conclusion, 3-year results of the PLATINUM randomized, controlled, clinical trial demonstrate comparable safety and efficacy outcomes of the PROMUS Element PtCr-EES and the XIENCE V CoCr-EES.