Fatty acid and cholesterol composition of the uterine artery intima in relation to menopausal status, age, and serum cholesterol

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• 作者：Jokela ; Hannu ; Salomä ; ki ; Anne ; Lehtimä ; ki ; Terho ; Teisala ; Klaus ; Heinonen ; Pentti K. ; et. al.
• 关键词：Atherosclerosis ; Lipids ; Menopause ; Uterine arteries
• 刊名：Maturitas
• 出版年：2004
• 出版时间：February 20, 2004
• 年：2004
• 卷：47
• 期：2
• 页码：115-122
• 全文大小：174 K

文摘

Objectives: Estrogens modulate lipid metabolism and the increased risk of atherosclerosis in postmenopausal women is at least partly due to the reduction of estrogen production after menopause. We studied the effect of menopause on the contents of long-chain fatty acids, free cholesterol (FC) and cholesterol ester (CE) in uterine artery wall. Methods: The uterine artery intima samples were obtained in connection with surgery of 21 postmenopausal and 51 premenopausal women. The amount of FC, CE and phospholipid fatty acids were measured by gas chromatography after extraction and fractionation and these lipid values were related to menopausal status, age and serum total and low-density lipoprotein (LDL) cholesterol levels. Results: Premenopausal females had significantly less intimal FC (161±50 vs. 407±276 μg/100 mg wet weight, P