Influence of an ionic liquid on the conformational sampling of Xaa-Pro dipeptides

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• 作者：Alexanndra J. Heyert^a ; Susan L. Knox^b ; Gerrick E. Lindberg^a ; ¹ ; ^{gerrick.lindberg@nau.edu} ; Joseph L. Baker^b ; ¹ ; ^{bakerj@tcnj.edu}
• 刊名：Journal of Molecular Liquids
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：66-75
• 全文大小：1819 K
• 卷排序：227

文摘

Room temperature ionic liquids can affect the cis/trans state of peptide bonds. Cis/trans isomerization of proline-containing dipeptides is studied in 4 solvents. [C4mpy][Tf2N] leads to large cis/trans isomerization barriers in Xaa-Pro dipeptides. Cis state of Trp-Pro is found to be the preferred conformation in [C4mpy][Tf2N]. Ramachandran space explored is less in IL than other studied solvents.