The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation
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- 作者：Lauren Waldron1 ; 2 ; Jeffrey D. Steimle8 ; Todd M. Greco7 ; Nicholas C. Gomez2 ; 4 ; Kerry M. Dorr1 ; 2 ; Junghun Kweon8 ; Brenda Temple6 ; Xinan Holly Yang8 ; Caralynn M. Wilczewski1 ; 2 ; Ian J. Davis3 ; 4 ; Ileana M. Cristea7 ; Ivan P. Moskowitz8 ; Frank L. Conlon1 ; 2 ; 3 ; 4 ; 5 ; frank_conlon@med.unc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：8 February 2016
- 年：2016
- 卷：36
- 期：3
- 页码：262-275
- 全文大小：4215 K
文摘
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Isolation and characterization of the endogenous cardiac TBX5 interactome
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TBX5 interacts biochemically and genetically with the NuRD repressor complex
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TBX5 represses inappropriate gene programs incompatible with cardiac development
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Human TBX5 mutations alter the NuRD interaction and correlate with septal defects