Tumor necrosis factor-Alpha stimulates cytokine expression and transient sensitization of trigeminal nociceptive neurons

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• 作者：Zachary L. Durham ^{zachdurham5@gmail.com} ; Jordan L. Hawkins ^{jhawkins415@gmail.com} ; Paul L. Durham ; ^{pauldurham@missouristate.edu}
• 关键词：CGRP ; calcitonin gene-related peptide ; PBS ; phosphate buffered saline ; TMJ ; temporomandibular joint ; TMD ; temporomandibular disorders
• 刊名：Archives of Oral Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：75
• 期：Complete
• 页码：100-106
• 全文大小：809 K
• 卷排序：75

文摘

Injection of TNF-α in TMJ increases nocifensive response to mechanical stimulation. TNF-α causes increase in level of multiple cytokines in trigeminal ganglion. Increased nocifensive response correlated with differential cytokine regulation.