Unusual products of the aqueous chlorination of atenolol

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• 作者：Marina DellaGreca ; Maria Rosaria Iesce ; Paola Pistillo ; Lucio Previtera ; Fabio Temussi
• 关键词：Atenolol ; Chlorination ; Dichlorinated product ; Phytotoxicity ; Lactuca sativa
• 刊名：Chemosphere
• 出版年：2009
• 出版时间：February 2009
• 年：2009
• 卷：74
• 期：5
• 页码：730-734
• 全文大小：172 K

文摘

The reaction of the drug atenolol with hypochlorite under conditions that simulate wastewater disinfection was investigated. The pharmaceutical reacted in 1 h yielding three products that were separated by chromatographic techniques and characterized by spectroscopic features. Two unusual products 2-(4-(3-(chloro(2-chloropropan-2-yl)amino)-2-hydroxypropoxy)phenyl) acetamide and 2-(4-(3-formamido-2-hydroxypropoxy)phenyl) acetamide were obtained along with 2-(4-hydroxyphenyl) acetamide. When the reaction was stopped at shorter times only 2-(4-(3-amino-2-hydroxypropoxy)phenyl) acetamide and the dichlorinated product were detected. Tests performed on the seeds of Lactuca sativa show that chlorinated products have phytotoxic activity.