Epidermal growth factor-like repeats of tenascin-C-induced constriction of cerebral arteries via activation of epidermal growth factor receptors in rats
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- 作者：Masashi Fujimotoa ; Masato Shibaa ; Fumihiro Kawakitaa ; Lei Liua ; Asuka Nakasakia ; Naoshi Shimojob ; Kyoko Imanaka-Yoshidab ; c ; Toshimichi Yoshidab ; c ; Hidenori Suzukia ; c ; suzuki02@clin.medic.mie-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACA ; anterior cerebral artery ; ANOVA ; analysis of variance ; BA ; basilar artery ; DMSO ; dimethyl sulfoxide ; EGF ; epidermal growth factor ; EGFR ; EGF receptor ; ERK ; extracellular signal-regulated kinase ; HE ; hematoxylin-eosin ; ICA ; internal carotid artery ; JNK ; c-Jun N-terminal kinase ; MCA ; middle cerebral artery ; PBS ; phosphate-buffered saline ; r-TNC ; recombinant tenascin-C ; SAH ; subarachnoid hemorrhage ; TLR4 ; toll-like receptor 4 ; TNC ; tenascin-C
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：1642
- 期：Complete
- 页码：436-444
- 全文大小：3070 K
文摘
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EGF-like repeats of TNC induced cerebral vasospasm-like prolonged vasoconstriction.
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EGF-like repeats of TNC activated EGFR and ERK1/2 in cerebral arteries in rats.
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EGFR inhibitor inactivated ERK1/2 in the smooth muscle cell layer of arteries.
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EGFR inhibitor attenuated vasoconstrictive effects of TNC.