MiR124 suppresses collagen formation of human tendon derived stem cells through targeting egr1
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- 作者：Bin Wanga ; b ; 1 ; Jia Guoa ; 1 ; Lu Fenga ; Chun-wai Suena ; Wei-ming Fuc ; fuweiming76@smu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jin-fang Zhanga ; b ; Gang Lia ; b ; gangli@cuhk.edu.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：col1a1 ; collagen type I alpha 1 ; col1a2 ; collagen type I alpha 2 ; dcn ; decorin ; egr1 ; early growth response-1 ; fmod ; fibromodulin ; fn1 ; fibronectin ; miRNAs ; microRNAs ; mkx ; mohawk homeobox ; scx ; scleraxis bHLH transcription factor ; TDSC ; tendon derived stem cell ; TGF-β ; Transforming growth factor β ; tnc ; tenascin C ; tnmd ; tenomodulin ; UTR ; untranslated region
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：347
- 期：2
- 页码：360-366
- 全文大小：1337 K
文摘
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A new role of miR124 in regulating collagen formation was postulated.
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The mechanism relies on microRNA through targeting egr1.
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new pathway provides alternative therapeutic strategy in tendon healing.