Tendon-Derived Stem Cells for Rotator Cuff Repair

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• 作者：Pietro Randelli ; MD^* ; ^&dagger ; ; ^{pietro.randelli@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Davide Cucchi ; MD^* ; ^&dagger ; ; Federico Cabitza ; Eng^&Dagger ; ; Riccardo Compagnoni ; MD^§ ; ; Alessandra Menon ; PhD^*
• 关键词：tendon-derived stem cells ; regenerative medicine ; rotator cuff repair ; shoulder tissues
• 刊名：Operative Techniques in Orthopaedics
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：26
• 期：3
• 页码：147-154
• 全文大小：2384 K

文摘

Rotator cuff tear is a common cause of shoulder pain and disability, and arthroscopic repair is a frequently performed procedure. To improve results and reduce failure rate of this surgery, biological solutions to enhance tendon repair are being investigated. Mesenchymal stem cells contribute in creating a suitable microenvironment for tissue repair, and therefore therapeutic use of tendon tissue-specific stem cells in clinical practice is one of the most promising challenges in regenerative medicine approaches to rotator cuff repair.

The aim of this article is to revise the current literature on tendon-derived stem cells for rotator cuff repair. Identification and characterization of a reservoir of progenitor cells in human shoulder periarticular tissues has been successfully confirmed by different authors. The first animal studies on the healing potential of these mesenchymal stem cells showed encouraging results. No clinical trials have been published yet. Rigorous preclinical translational studies are needed to ensure safety and efficacy of stem cells–based treatments before routine use in clinical practice.