Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent d-amino acid oxidase inhibitor
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- 作者：Dongsheng Xie1 ; Jun Lu1 ; Jin Xie ; Junjun Cui ; Teng-Fei Li ; Yan-Chao Wang ; Yuan Chen ; Nian Gong ; Xin-Yan Li ; Lei Fu ; leifu@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yong-Xiang Wang ; yxwang@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：D-amino acid oxidase ; DAAO inhibitors ; 5-Azaquinoxaline-2 ; 3-diones ; Analgesic effects ; 8-Chloro-1 ; 4-dihydropyrido[2 ; 3-b]pyrazine-2 ; 3-dione
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：117
- 期：Complete
- 页码：19-32
- 全文大小：3952 K
文摘
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Disclosed 5-azaquinoxaline-2,3-diones as novel noncarboxylic DAAO inhibitors.
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Confirmed the analgesic effects of DAAO inhibitor based on a new scaffold.
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Provided a new class of chemical entities for potential analgesic application.