Antiproliferative cyclodepsipeptides from the marine actinomycete Streptomyces sp. P11-23B downregulating the tumor metabolic enzymes of glycolysis, glutaminolysis, and lipogenesis

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• 作者：Xuewei Ye^a ; Komal Anjum^a ; Tengfei Song^a ; Wenling Wang^a ; Ying Liang^a ; Mengxuan Chen^a ; Haocai Huang^a ; Xiao-Yuan Lian^b ; ^{xylian@zju.edu.cn} ; Zhizhen Zhang^a ; ^{zzhang88@zju.edu.cn}
• 关键词：Marine actinomycete ; Streptomyces sp. ; Cyclodepsipeptides ; Antiproliferative agents ; Glioma cells ; Tumor metabolic regulators
• 刊名：Phytochemistry
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：135
• 期：Complete
• 页码：151-159
• 全文大小：1433 K
• 卷排序：135

文摘

Streptodepsipeptides P11A and P11B were isolated from Streptomyces sp. Streptodepsipeptides remarkably inhibited proliferation of glioma cells. Streptodepsipeptide P11A blocked glioma cell cycle at G0/G1 phase. Streptodepsipeptide P11A downregulated expression of glioma metabolic enzymes.