The influence of pore size and stiffness on tenocyte bioactivity and transcriptomic stability in collagen-GAG scaffolds

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• 作者：William K. Grier^a ; Ehiremen M. Iyoha^a ; Brendan A.C. Harley^a ; ^b ; ^{bharley@illinois.edu}
• 关键词：Collagen ; Scaffold ; Pore size ; Crosslinking ; Tenocyte ; Bioactivity
• 刊名：Journal of the Mechanical Behavior of Biomedical Materials
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：65
• 期：Complete
• 页码：295-305
• 全文大小：1928 K
• 卷排序：65

文摘

Collagen scaffold anisotropy promotes maintenance of tenocyte phenotype. Tenocyte phenotype preserved in scaffolds that resist cell-mediated contraction. Pore size and crosslinking independently tune scaffold strut flexural rigidity. Crosslinking more effectively reduces tenocyte contraction. Increased contraction correlated with upregulated matrix remodeling.