Epigenetic and gene expression changes in the adolescent brain: What have we learned from animal models?
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- 作者：Richelle Mychasiuka ; rmmychas@ucalgary.ca" class="auth_mail" title="E-mail the corresponding author ; Gerlinde A.S. Metzb
- 关键词：Prefrontal cortex ; DNA methylation ; Histone modification ; Development
- 刊名：Neuroscience & Biobehavioral Reviews
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：70
- 期：Complete
- 页码：189-197
- 全文大小：1078 K
文摘
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Human adolescence can be reliably modeled in rodents and non-human primates.
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Extensive epigenetic modification occurs in the brain during adolescence.
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Animal models permit the investigation of normal adolescent epigenetic programing.
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Pre- and post-natal experiences of the individual modify developmental trajectories.