Cross-Sectional Survey to Assess the Status of Lipid Management in High-Risk Patients With Dyslipidemia: Clinical Impact of Combination Therapy With Ezetimibe

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• 作者：Tamio Teramoto ; MD¹ ; ^{ttera@med.teikyo-u.ac.jp} ; Atsunori Kashiwagi ; MD² ; Shun Ishibashi ; MD³ ; Hiroyuki Daida ; MD⁴ ; Japan Lipid Guideline Achievement Program Investigators
• 关键词：cross-sectional study ; dyslipidemia ; ezetimibe ; hydroxymethylglutaryl-CoA reductase inhibitors ; lipid management
• 刊名：Current Therapeutic Research
• 出版年：2012
• 出版时间：February-April, 2012
• 年：2012
• 卷：73
• 期：1-2
• 页码：1-15
• 全文大小：525 K

文摘

Background

Previous retrospective surveys have shown that lipid management goals are well achieved in patients with dyslipidemia at relatively low risk for atherosclerotic diseases. However, more than half of patients in high-risk groups have not achieved the management goals. Since these surveys, newer medications, including rosuvastatin and ezetimibe, have emerged in clinical practice that may influence lipid management.

Objective

To assess the current status of lipid management in high-risk patients, we conducted a cross-sectional study between January and March 2010.

Methods

Eligible patients were those with dyslipidemia who were classified into the primary prevention high-risk or secondary prevention groups according to the Japan Atherosclerosis Society guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases. Patient data were collected from 300 randomly selected physicians at hospitals and clinics across Japan if patients had been receiving the same statin with or without other lipid-lowering agents for ? months. The main outcome was the percentage of patients who achieved the serum LDL-C goal according to the guideline.

Results

Data were collected from 1720 patients. The LDL-C goal was achieved in 56.5 % of patients (447 of 791) in the primary prevention high-risk group and in 24.5 % (103 of 420) in the secondary prevention group by statin monotherapy. For patients who had not reached the LDL-C goal with statin therapy alone, 53.8 % (113 of 210) in the primary prevention high-risk group and 63.8 % (111 of 174) in the secondary prevention group achieved their lipid management goal with the addition of ezetimibe. Ezetimibe significantly lowered mean serum LDL-C levels by 17.9 % to 34.6 % when added to various statins (P < 0.001).

Conclusions

Although strong statins are available, lipid management in high-risk patients remains unsatisfactory. More aggressive treatment is needed for these patients.