An amphoteric mesoporous silica catalyzed aldol reaction

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• 作者：Niclas Solin ; Lu Han ; Schunai Che ; Osamu Terasaki
• 关键词：Mesoporous silica ; Catalysis ; Aldol reaction ; Bi-functional materials
• 刊名：Catalysis Communications
• 出版年：2009
• 出版时间：20 May 2009
• 年：2009
• 卷：10
• 期：10
• 页码：1386-1389
• 全文大小：224 K

文摘

A bi-functional mesoporous silica material, containing both carboxylic acid and amino groups, acts as a catalyst for the reaction between aldehydes and carbon nucleophiles. We demonstrate reaction conditions under which even aldehydes containing deactivating electron donating groups, or sterically demanding substituents, undergo the catalyzed reaction with acetone, affording primarily the condensation products. Moreover, we demonstrate that acetophenone and ethyl methyl ketone can replace acetone as nucleophile. The bi-functional mesoporous silica is a convenient catalyst, as it is simple to remove from the reaction media, thereby facilitating workup.