Role of serotonergic-related systems in suicidal behavior: Data from a case–control association study

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• 作者：Pilar A. Saiz^a ; ^{frank@uniovi.es" rel="nofollow} ; Paz Garc&#xed ; a-Portilla^a ; Begoñ ; a Paredes^b ; Paul Corcoran^c ; Celso Arango^d ; Blanca Morales^e ; Emilio Sotomayor^f ; Victoria Alvarez^e ; Eliecer Coto^e ; Gerardo Fló ; rez^g ; Mar&#xed ; a-Teresa Bascaran^a ; Manuel Bousoñ ; o^a ; Julio Bobes^a
• 关键词：Angiotensin converting enzyme ; Apolipoprotein E ; Interleukin-1 gene complex ; Serotonin system ; Suicidal behavior
• 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
• 出版年：2011
• 出版时间：1 August 2011
• 年：2011
• 卷：35
• 期：6
• 页码：1518-1524
• 全文大小：205 K

文摘

Objective

To investigate whether functional polymorphisms directly (HTR2A and SLC6A4 genes) or indirectly (IL-1 gene complex, APOE and ACE genes) related with serotonergic neurotransmission were associated with suicidal behavior.

Subjects and methods

227 suicide attempters, 686 non-suicidal psychiatric patients, and 420 healthy controls from a homogeneous Spanish Caucasian population were genotyped using standard methods.

Results

There were no differences in genotype frequencies between the three groups. The −1438A/G [χ² (df) = 9.80 (2), uncorrected p = 0.007] and IL-1α −889C/T [χ² (df) = 8.76 (2), uncorrected p = 0.013] genotype frequencies between impulsive and planned suicide attempts trended toward being different (not significant after Bonferroni correction). Suicide attempts were more often impulsive in the presence of −1438G/G or IL-1α −889C/T or C/C genotypes. There was interaction between the polymorphism 5-HTTLPR and age [LRT (df) = 6.84 (2), p = 0.033] and between the polymorphisms APOE and IL-1RA (86 bp)_n [LRT (df) = 12.21 (4), p = 0.016] in relation to suicide attempt lethality.

Conclusion

These findings further evidence the complexity of the association between genetics and suicidal behavior, the need to study homogenous forms of the behavior and the relevance of impulsive and aggressive traits as endophenotypes for suicidal behavior.