Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis
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- 作者：Maria Moksnes Bjaanæ ; sa ; b ; 1 ; mamok@rr-research.no" class="auth_mail" title="E-mail the corresponding author ; Thomas Fleischera ; e ; 1 ; thomas.fleischer@rr-research.no" class="auth_mail" title="E-mail the corresponding author ; Ann Rita Halvorsena ; Ann.Rita.Halvorsen@rr-research.no" class="auth_mail" title="E-mail the corresponding author ; Antoine Daunayh ; antoine.daunay@cephb.fr" class="auth_mail" title="E-mail the corresponding author ; Florence Busatog ; busato@cng.fr" class="auth_mail" title="E-mail the corresponding author ; Steinar Solbergc ; Steinar.Solberg@oslo-universitetssykehus.no" class="auth_mail" title="E-mail the corresponding author ; Lars Jø ; rgensenc ; Lars.Jorgensen@oslo-universitetssykehus.no" class="auth_mail" title="E-mail the corresponding author ; Elin Kurea ; Elin.Kure@rr-research.no" class="auth_mail" title="E-mail the corresponding author ; Hege Edvardsena ; 2 ; hege.edvardsen@abbvie.com" class="auth_mail" title="E-mail the corresponding author ; Anne-Lise Bø ; rresen-Dalea ; d ; a.l.borresen-dale@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author ; Odd Terje Brustuguna ; b ; ot.brustugun@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jö ; rg Tostg ; tost@cng.fr" class="auth_mail" title="E-mail the corresponding author ; Vessela Kristensena ; e ; f ; v.n.kristensen@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author ; Å ; slaug Hellanda ; b ; aslaug.helland@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA methylation ; Lung cancer ; EGFR ; NSCLC ; LUAD ; TP53 ; mRNA ; Adenocarcinoma ; KRAS ; Prognosis ; CpG ; TP53 ; 450K
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：10
- 期：2
- 页码：330-343
- 全文大小：2235 K
文摘
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Extensive DNA methylation changes linked to immune signaling.
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DNA methylation in EGFR-mutated tumors associated with oncogenic pathways.
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DNA methylation with both positive and negative correlation with mRNA expression.
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DNA methylation signature with prognostic information.