The estrogen-dependent baroreflex dysfunction caused by nicotine in female rats is mediated via NOS/HO inhibition: Role of sGC/PI3K/MAPKERK
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- 作者：Mohamed A. Fouda ; Hanan M. El-Gowelli ; Sahar M. El-Gowilly ; Mahmoud M. El-Mas ; mahelm@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BP ; blood pressure ; BRS ; baroreflex sensitivity ; ERK ; extracellular signal-regulated kinases ; E2 ; estradiol ; HR ; heart rate ; HO ; heme oxygenase ; JNK ; c-Jun. amino (N)-terminal kinases ; L-NAME ; Nω-Nitro-l-arginine methyl ester hydrochloride ; MAPKs ; mitogen activated protein kinases ; MAP ; mean arterial pressure ; NO ; nitric oxide ; NOS ; nitric oxide synthase ; OVX ; ovariectomy ; PI3K ; phosphatidylinositol 3-kinase ; sGC ; soluble guanylate cyclase ; ZnPP ; zinc protoporphyrin IX
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：289
- 期：3
- 页码：466-473
- 全文大小：843 K
文摘
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Hemin or l-arginine blunts baroreflex dysfunction caused by nicotine in OVXE2 rats.
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NO/CO crosstalk mediates favorable baroreflex effect of hemin or l-arginine.
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Central sGC/PI3K/MAPKERK is required for hemin facilitation of baroreflexes.
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The favorable baroreflex action of hemin is independent of estrogen receptors.