The Asian-American variant of human papillomavirus type 16 exhibits higher activation of MAPK and PI3K/AKT signaling pathways, transformation, migration and invasion of primary human keratinocytes
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- 作者：Jimena Hochmanna ; jimena.valls@icesp.org.br" class="auth_mail" title="E-mail the corresponding author ; Joã ; o S Sobrinhoa ; simao_j@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Luisa L. Villaa ; b ; luisa.villa@hc.fm.usp.br" class="auth_mail" title="E-mail the corresponding author ; Laura Sicheroa ; laura.sichero@hc.fm.usp.br" class="auth_mail" title="E-mail the corresponding author ; lsichero@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：(Af) ; African ; (As) ; Asian ; (AA) ; Asian-American ; (CREB) ; cAMP response element-binding protein ; (CIN) ; cervical intraepithelial neoplasia ; (EMT) ; Ephitelial to mesenchymal transition ; (E) ; European ; (E-P) ; European prototype ; (ERK2) ; extracellular signal regulated kinase ; (GSK-3b) ; glycogen synthase kinase ; (HSP-27) ; heat shock protein 27 ; (HBV) ; hepatitis B virus ; (HPV) ; human papillomavirus ; (MAPK-JNK) ; Jun amino-terminal kinases ; (KSFM) ; keratinocyte serum free medium ; (MAP3K or MAPKKK) ; MAP
- 刊名：Virology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：492
- 期：Complete
- 页码：145-154
- 全文大小：1222 K
文摘
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We evaluated activation of MAPK and PI3K/AKT pathways in HPV-16 E-P, AA, and E-350G transduced PHKs.
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We accessed migration, anchorage independent growth and invasion of different HPV-16 molecular variants transduced cells.
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MEK1, ERK2, AKT2 activation may influence cellular behavior prompting AA PHKs to induce carcinogenesis more efficiently.