Soluble ST2 suppresses the effect of interleukin-33 on lung type 2 innate lymphoid cells
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- 作者：Hiroko Hayakawa ; Morisada Hayakawa ; morisada@jichi.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Shin-ichi Tominaga
- 关键词：ILC2 ; type 2 innate lymphoid cells ; IL ; interleukin ; Th2 ; type 2 helper T ; NF-κB ; nuclear factor-kappa B ; MAPK ; mitogen-activated protein kinases ; JNK ; c-Jun amino-terminal kinases ; ERK ; extracellular signal-regulated kinases ; FSC ; forward scatter ; SSC ; side scatter ; CFSE ; carboxyfluorescein diacetate succinimidyl ester
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：5
- 期：Complete
- 页码：401-407
- 全文大小：2193 K
文摘
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Expression of IL-33 receptor in lung ILC2 is upregulated by IL-33 stimulation.
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Soluble ST2 functions as a decoy receptor for IL-33.
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Soluble ST2 protects naïve lung ILC2 from stimulation by IL-33.