Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells
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- 作者：Renu Jain1 ; Yi Chen1 ; Yuka Kanno2 ; Barbara Joyce-Shaikh1 ; Golnaz Vahedi2 ; Kiyoshi Hirahara2 ; Wendy M. Blumenschein1 ; Selvakumar Sukumar1 ; Christopher J. Haines1 ; Svetlana Sadekova1 ; Terrill K. McClanahan1 ; Mandy J. McGeachy1 ; 3 ; John J. O&rsquo ; Shea2 ; Daniel J. Cua1 ; daniel.cua@merck.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：19 January 2016
- 年：2016
- 卷：44
- 期：1
- 页码：131-142
- 全文大小：3820 K
文摘
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IL-23-dependent Blimp-1 enhances Th17 pathogenic factors including GM-CSF and IFN-γ
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Distal Lck-Cre-mediated Blimp-1 deletion in peripheral T cells ameliorates EAE
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Blimp-1 co-localizes with RORγt and STAT-3 at Il23r, Il17a, and Csf2 enhancer sites
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Blimp-1 also represses Il2 and Bcl6, which destabilize the Th17 inflammatory program