Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability
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- 作者：Jacob S. Lee1 ; 3 ; Cristina M. Tato1 ; 3 ; 4 ; Barbara Joyce-Shaikh1 ; Muhammet F. Gulen2 ; Corinne Cayatte1 ; 5 ; Yi Chen1 ; Wendy M. Blumenschein1 ; Michael Judo1 ; Gulesi Ayanoglu1 ; Terrill K. McClanahan1 ; Xiaoxia Li2 ; Daniel J. Cua1 ; daniel.cua@merck.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2015
- 出版时间：20 October 2015
- 年：2015
- 卷：43
- 期：4
- 页码：727-738
- 全文大小：2957 K
文摘
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Neutralizing IL-17 results in increased gut permeability in a DSS injury model
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γδ T cells are the major source of gut-protective IL-17 and are IL-23 independent
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IL-17 regulates the cellular localization of the tight junction protein occludin
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The data explain IBD exacerbation with anti-IL-17 but amelioration with anti-IL-23