Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation
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- 作者：Zhifang Cao1 ; 2 ; Kara L. Conway1 ; 2 ; 3 ; Robert J. Heath1 ; 2 ; 3 ; Jason S. Rush3 ; Elizaveta S. Leshchiner3 ; Zaida G. Ramirez-Ortiz4 ; Natalia B. Nedelsky1 ; 2 ; Hailiang Huang3 ; 5 ; Aylwin Ng1 ; 2 ; 3 ; Agnè ; s Gardet1 ; 2 ; Shih-Chin Cheng6 ; Alykhan F. Shamji3 ; John D. Rioux7 ; Cisca Wijmenga8 ; Mihai G. Netea6 ; Terry K. Means4 ; Mark J. Daly3 ; 5 ; Ramnik J. Xavier1 ; 2 ; 3 ; xavier@molbio.mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2015
- 出版时间：20 October 2015
- 年：2015
- 卷：43
- 期：4
- 页码：715-726
- 全文大小：2213 K
文摘
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A CARD9 allele that protects against disease acts in a dominant-negative manner
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TRIM62-mediated ubiquitination of CARD9 is essential for CARD9 activation
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Ubiquitination by TRIM62 does not occur in a protective variant of CARD9
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Trim62-deficient mice show increased susceptibility to fungal infection