文摘
Various genetic mutants of NDH2 were created in bloodstream form Trypanosoma brucei. NDH2 null mutants showed a substantial reduction in growth. NDH2 ablation in a complex I deficient background led to severe growth restriction. Upon prolonged culture, parasites partially compensated for NDH2 deficiency. Loss of NDH2 led to reduced acetate, potentially contributing to the growth defect.