Inverse relationship between high-density lipoprotein cholesterol raising and high-sensitivity C-reactive protein reduction in older patients treated with lipid-lowering therapy
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- 作者：W. Virgil Brown ; MDa ; wbrow925@bellsouth.net" class="auth_mail" title="E-mail the corresponding author ; JoAnne M. Foody ; MDb ; Franklin J. Zieve ; MD ; PhDc ; Joanne E. Tomassini ; PhDd ; Arvind Shah ; PhDd ; Andrew M. Tershakovec ; MD ; MPHd
- 关键词：Atorvastatin ; Ezetimibe ; HDL-C ; hsCRP ; Hypercholesterolemia ; Vytorin
- 刊名：Journal of Clinical Lipidology
- 出版年：2016
- 出版时间：January-February 2016
- 年：2016
- 卷：10
- 期：1
- 页码：116-123
- 全文大小：647 K
文摘
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Relationships between high-sensitivity C-reactive protein (hsCRP) and lipids other than low-density lipoprotein cholesterol are not well described.
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Older high cardiovascular risk patients were treated with ezetimibe/simvastatin or atorvastatin.
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hsCRP and lipids correlated weakly at baseline, improving slightly on treatment.
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Baseline and study end levels, and changes in hsCRP and high-density lipoprotein cholesterol, correlated inversely.
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The inverse relationship of high-density lipoprotein cholesterol and hsCRP may reflect anti-inflammatory effects.