Nano bioresearch approach by microtechnology
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- 作者：Dominique Collard1 ; 2 ; collard@iis.u-tokyo.ac.jp ; Soo Hyeon Kim2 ; Toshihisa Osaki3 ; Momoko Kumemura1 ; 2 ; Beomjoon Kim1 ; 2 ; Dominique Fourmy1 ; 5 ; Teruo Fujii1 ; 2 ; Shoji Takeuchi1 ; 2 ; Stanislav L. Karsten4 ; Hiroyuki Fujita1 ; 2
- 刊名：Drug Discovery Today
- 出版年：2013
- 出版时间：June, 2013
- 年：2013
- 卷：18
- 期：11-12
- 页码：552-559
- 全文大小：3899 K
文摘
To progress in basic science and drug development, convenient methodology for detecting specific biological molecules and their interaction in living organism is in high demand. After more than 20 years of increasing research efforts, micro and nanotechnologies are now mature to propose a new class of miniature devices and principles enabling compartmentalized bioassays. Among them, this review proposes various examples that include array of electro-active microwells for highly parallel single cell analysis, cost-effective nanofluidic for DNA separation, parallel enzymatic reaction in 100 pL droplet and high-throughput platform for membrane proteins assays. The micro devices are presented with relevant experiments to foresee their future contribution to translational research and drug discovery.