Variation in the HFE gene is associated with the development of bleomycin-induced pulmonary toxicity in testicular cancer patients
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- 作者：Gabriela G.F. van der Schoota ; Nico-Derk L. Westerinka ; Sjoukje Lubbertsa ; Janine Nuvera ; Nynke Zwarta ; Annemiek M.E. Walenkampa ; Johan B. Wempeb ; Coby Meijera ; Jourik A. Gietemaa ; j.a.gietema@umcg.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Testicular neoplasms ; Survivors ; Antineoplastic agents ; HFE ; Bleomycin ; Cisplatin ; Toxicity ; Variation
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：59
- 期：Complete
- 页码：134-141
- 全文大小：377 K
文摘
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Variants in the HFE gene, H63D and C282Y, lead to accumulation of extracellular iron in lungs.
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Iron handling may play a role in development of bleomycin- and cisplatin-induced toxicity.
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The H63D variant is associated with a higher prevalence of bleomycin-induced pulmonary toxicity.