Multiple exposures to indoor contaminants: Derivation of benchmark doses and relative potency factors based on male reprotoxic effects
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- 作者：K. Fourniera ; b ; kevin.fournier@ehesp.fr" class="auth_mail" title="E-mail the corresponding author ; C. Tebbyc ; cleo.tebby@ineris.fr" class="auth_mail" title="E-mail the corresponding author ; F. Zemanc ; florence.zeman@ineris.fr" class="auth_mail" title="E-mail the corresponding author ; P. Glorenneca ; b ; Philippe.glorennec@ehesp.fr" class="auth_mail" title="E-mail the corresponding author ; D. Zmirou-Naviera ; b ; d ; denis.zmirou@ehesp.fr" class="auth_mail" title="E-mail the corresponding author ; N. Bonvallota ; b ; nathalie.bonvallot@ehesp.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Semi-volatile organic compounds ; Benchmark doses ; Cumulative risk assessment ; Reproduction ; Mixture ; Toxicity
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：23-30
- 全文大小：826 K
文摘
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Semi-volatile organic compounds (SVOCs) detected in more than 10% of French dwelling were selected.
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SVOCs were grouped according to their reprotoxic mode of action.
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Benchmark Doses and Relative Potency Factors based on a decrease in testosterone level in male rodent were derived.
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The main limitation is the lack of comparable toxicological data.