Sawhorse-type diruthenium tetracarbonyl complexes containing biologically relevant acids

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• 作者：Justin P. Johnpeter ; Bruno Therrien ; ^{bruno.therrien@unine.ch}
• 关键词：Dinuclear complexes ; Carbonyl ligands ; Carboxylato bridges ; Ruthenium ; Porphyrin ligands ; Biologically active acids
• 刊名：Inorganica Chimica Acta
• 出版年：2013
• 出版时间：1 January, 2013
• 年：2013
• 卷：394
• 期：Complete
• 页码：723-728
• 全文大小：863 K

文摘

The reaction between the biologically active acids probenecid (HO₂CC₁₂H₁₈NO₂S), indomethacin (HO₂CC₁₈H₁₅ClNO₂) and sulindac (HO₂CC₁₉H₁₆FOS) with Ru₃(CO)₁₂, followed by addition of axial ligands (L), such as pyridine, triphenylphosphine, or 5-(4-pyridyl)-10,15,20-triphenylporphyrin, generates a series of stable diruthenium tetracarbonyl complexes of the formula Ru₂(CO)₄(¦Ì₂-¦Ç²-O₂CC₁₂H₁₈NO₂S)₂L₂, Ru₂(CO)₄(¦Ì₂-¦Ç²-O₂CC₁₈H₁₅ClNO₂)₂L₂ and Ru₂(CO)₄(¦Ì₂-¦Ç²-O₂CC₁₉H₁₆FOS)₂L₂, respectively. The molecular structure of 1a ¡¤ C₆H₆ was solved by single-crystal X-ray structure analysis and a typical diruthenium tetracarbonyl backbone bridged by the carboxylato ligands and two axial triphenylphosphine ligands was revealed. The benzene molecule sits between two probenecid units, and is involved in ¦Ð-stacking interactions with the aromatic part of probenecid. Despite the presence of biologically relevant derivatives and carbonyl groups within the sawhorse-type dinuclear complexes, all systems show no cytotoxicity towards human cancer cells, presumably due to the high lipophilicity of these neutral complexes.