Asymmetric synthesis of chiral tectons with tetrapodal symmetry: fourfold asymmetric reactions

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• 作者：Oliver Plietzsch ; Christine Inge Schilling ; Martin Nieger ; Thierry Muller ; Stefan Brä ; se
• 刊名：Tetrahedron: Asymmetry
• 出版年：2010
• 出版时间：23 June 2010
• 年：2010
• 卷：21
• 期：11-12
• 页码：1474-1479
• 全文大小：777 K

文摘

The diastereoselective fourfold addition to Ellman-type imines furnished after deprotection the tetrapodal amines in excellent yields. The unprecedented asymmetric fourfold addition of hydride and alkylzinc reagents to tetrapodal ketones and aldehydes, respectively, is achieved by employing CBS-reduction or [2.2]paracyclophane-based ketimine ligands with good to excellent global enantiomeric ratios.