An efficient and economical synthesis of 5-substituted 1H-tetrazoles via Pb(II) salt catalyzed [3+2] cycloaddition of nitriles and sodium azide

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• 作者：Rama Kant ; Vishal Singh ; Alka Agarwal ; ^{agarwal.dralka@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：5-Substituted 1H-tetrazoles ; [3+2] cycloaddition ; Lead chloride ; Recyclability ; X-ray analysis
• 刊名：Comptes Rendus Chimie
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：19
• 期：3
• 页码：306-313
• 全文大小：2006 K

文摘

A simple, mild and efficient method is developed for the synthesis of 5-substituted 1H-tetrazoles. Out of three used Pb(II) catalysts, lead chloride (PbCl₂) has been found to be an efficient catalyst for [3+2] cycloaddition of NaN₃ with aromatic and aliphatic nitriles to afford 5-substituted 1H-tetrazoles. The catalyst is reusable up to four cycles with consistent activity. The cost effectiveness and easy availability of the catalyst, simple methodology, excellent yield and easy work-up are the additional advantages.